Your English writing platform
Discover LudwigSuggestions(5)
Exact(12)
Concentrations of genetic mutations have more to do with family and intermarriage patterns that often overlap with race, he said.
Those who have these mutations have more neural connections--but also more opportunities for 'breakdowns' in the neural pathways.
Our comprehensive exploration of nonsense polymorphisms showed that nonsense SNPs exist at a lower density than nonsynonymous SNPs, suggesting that nonsense mutations have more severe effects than amino acid changes.
Regarding the 4 remaining mutants, His51Ala, His57Asp, Cys138Ala and Phe13Leu, their consequences on unfolding curves and Tm shifts were less pronounced, suggesting that these mutations have more limited effects on folding and stability of MtPncA.
Although the biological effects of nonsense mutations appear to vary widely depending on their positions and the genes, the low density of nonsense SNPs that we found suggests that nonsense mutations have more disadvantageous effects than nonsynonymous mutations.
However, other causative A-T mutations have more recently been identified in these families (Børresen-Dale, unpublished).
Similar(48)
In addition, patients with these mutations had more persistent eczema.
Our study similarly indicates that children with frameshift mutations had more gastrointestinal polyps and received more endoscopic screenings and more surgical interventions.
Tumours with TP53 mutations had more aberrations (median of 9.0 per tumour) compared to those without (median of 2.0) (P = 0.002), and gain of 8q23 24 and loss of 18qcen-21 were significantly associated with TP53 mutations (P = 0.04 and 0.02 respectively).
Our data indicates that the APP K16N mutation has more than one property to render it pathogenic.
Likewise, the two clinical ALL cases with a FLT3 ITD mutation had more than 30-fold increased expression relative to the ALL case without a FLT3 ITD mutation.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com