Sentence examples for mutational hotspots for from inspiring English sources

First is the absence of any other repetitive DNA at the breakpoints, despite the expectation that IRs at inversion breakpoints should be mutational hotspots for subsequent structural and nucleotide variation [42].

These codons are recognized as mutational hotspots for RAS genes (Prior et al., 2012, Smith et al., 2010).

Alu elements are normally located within introns and 3′ untranslated regions of genes, which are considered mutational "hotspots" for large gene rearrangements [ 29].

However, the presence of Tn10 in the minicircle DNA producer strain is undesirable since some human therapeutic genes contain potential mutational hotspots for this element (5'-GCTNAGC-3' [ 13]).

The chromosomal distribution of young gene duplicates can elucidate whether there exist certain mutational hotspots for their origin with respect to specific chromosomes as well as locations along the gradient of a chromosome.

However, the patients with the Val162Met mutation did not share a common haplotype, suggesting independently arising mutations in the same residue, possibly pointing towards a mutational hotspot for RAB7.

The residue Arg84 is a clear mutational hotspot for PPS.

The DNA sequence of the 12-mer and the first 12-nucleotides of the 26-mer template was the same, and this sequence was taken from codon 272 275 of the p53 gene, in which the lesion was incorporated at the second nucleotide of codon 273, a well-known mutational hotspot for human cancer.

Glazko and coworkers show, using three statistical tests developed for the purpose, that the mutational hotspots of the TP53 gene evolve by positive selection.

Mutation screening of PIK3CA was performed for exons 9 and 20, covering the mutational hotspots; and for exon 18, from which a mutation was found in a gastric cancer.

Many of the mutated ESTs contain so-called mutational hotspots which, for the purpose of this study, were operationally defined as sites with three or more mutations (Tables 2 and 3; see Additional file 1 ).