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Exact(5)
Similarly, a sample containing a hemizygous mutation will show 33% of mutated template.
We also asked whether tumour cell lines with the same mutation will show similar cellular response to APR-246.
Markers that are on the opposite sides of the mutation will show recombination in the same individuals if recombination events happened between both flanking markers and the mutation.
However, we caution that the study was not intended or designed to demonstrate that all renal carcinomas arising in the context of SDH mutation will show this morphology.
This minor change suggests that the mutation will show either no effect or an insignificant structural change in the stability of the protein with age that could potentially appear at a very slow rate.
Similar(55)
Such an approach assumes that true somatic mutations will show strong evidence of their existence in multiple programs, and that errors made by individual algorithms are unlikely to intersect.
Consequently, the question that a potential rational design experiment might want to address is which mutation will likely show the most pronounced affect, assuming that a reduction in translation initiation correlates with a smooth transition from the wildtype structure to a conformationally rearranging one without getting trapped in local minima.
Comparison of the sets of mutated genes from different examples of the same tumour will show which mutations are coincidences, and which are causes.
Comparing cancerous tissue from different individuals will show which mutations are important.
Second, we predict that cancers with activating mutations in RHEB, or inactivating mutations in DEPDC5, NPRL2, and NPRL3, will show similar strong response to rapalogs.
Given that three to four pairs of dominant markers can span the entire chromosome, only one of these pairs will show that the mutation is inside its boundaries.
Related(20)
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