Sentence examples for mutation was highly from inspiring English sources

The DLK1 c.639C>T mutation was highly polymorphic in all breeds analyzed and C allele was predominant in Landrace and Duroc while T allele was more frequent in Pietrain and Puławska breed.

The mutation was highly effective in attenuating the motor-stimulating effect of acute NMDAR blockade by phencyclidine, although no appreciable elevation in NMDAR-mediated excitatory postsynaptic currents (EPSC) was observed in the hippocampus.

Moreover, in the breast cancer brain metastasis sequenced by Ding et al. (2010), the RBM47 mutation was highly enriched when compared to the primary tumor.

In contrast, the second study including 30 MCRC patients reported that KRAS mutation was highly predictive of tumour resistance to cetuximab (Lievre et al, 2006).

Sir, We reported last year, in the British Journal of Cancer, in a series of 59 metastatic colorectal cancer (MCRC) patients treated with cetuximab-based chemotherapy (CT), that KRAS mutation was highly predictive of treatment resistance and that progression-free survival was significantly increased in wild-type KRAS compared with mutant KRAS patients (Di Fiore et al, 2007).

The presence of this mutation is highly correlated to advanced stages of disease.

The mutation is highly penetrant in both roots and male meiocytes.

The L444P recurrent mutation is highly associated with neuronopathic variants of Gaucher disease, and is the most common Gaucher disease allele world-wide [2].

This cluster of RAS mutants (6 of 6 cell lines harboring RAS mutation) is highly unlikely to have occurred by chance (p = 0.001, permutation test, n = 100,000).

The other is the rare mutation hypothesis, which proposes that schizophrenia is caused by rare mutations with a high clinical penetrance, and the pathogenic mutation is highly individualized in each affected patient or family [27].

Published data on RAS mutation is highly variable with respect to frequency, the distribution of codon 12 and 13 vs. codon 61 mutations in HRAS, and the proportion between HRAS, KRAS, and NRAS mutations [5], [34], [35], [36].