Sentence examples for mutation were highly from inspiring English sources

Indeed, our most recent findings demonstrated that HPV-positive SCC tumorgrafts with activating PIK3CA mutation were highly responsive to PI3K-targeted therapy [ 15].

Blast alignment results indicated that the flanking amino acid regions at the site of the S168F mutation were highly conserved throughout species (Table 3).

Iindividuals carrying this mutation were highly susceptible to hypertension and coronary artery disease supporting the protective role this protein plays [ 42].

Introduction of the mutation was highly efficient, with almost 100% of genomic DNA isolated from tomato cells of the regenerated generation (T0) having the desired mutation, with no off-target mutations.

The DLK1 c.639C>T mutation was highly polymorphic in all breeds analyzed and C allele was predominant in Landrace and Duroc while T allele was more frequent in Pietrain and Puławska breed.

The mutation was highly effective in attenuating the motor-stimulating effect of acute NMDAR blockade by phencyclidine, although no appreciable elevation in NMDAR-mediated excitatory postsynaptic currents (EPSC) was observed in the hippocampus.

The presence of this mutation is highly correlated to advanced stages of disease.

The mutation is highly penetrant in both roots and male meiocytes.

The L444P recurrent mutation is highly associated with neuronopathic variants of Gaucher disease, and is the most common Gaucher disease allele world-wide [2].

This cluster of RAS mutants (6 of 6 cell lines harboring RAS mutation) is highly unlikely to have occurred by chance (p = 0.001, permutation test, n = 100,000).

The other is the rare mutation hypothesis, which proposes that schizophrenia is caused by rare mutations with a high clinical penetrance, and the pathogenic mutation is highly individualized in each affected patient or family [27].