Sentence examples for mutation that renders from inspiring English sources

Leu3 activity was elevated through overexpression and the introduction of a mutation that renders the protein constitutively active.

While recognizing that there are advantages to conditional- or regional-specific mutations; as a first step, we examined LTP in a line of mice containing a mutation that renders the PER2 protein non-functional (Zheng et al., 1999).

A recent study has provided compelling evidence that it activates AMPK in an indirect manner via an increase in AMP ATP and ADP ATP ratios using an engineered cell line expressing AMPK complexes bearing either the wild-type γ2 isoform or Arg531 → Gly mutation that renders γ2 complexes insensitive to the effects of ADP and AMP on phosphorylation [ 33].

Wright et al.[ 238] reported that the profile of ATH development was unaffected in Apoe−/− mice additionally carrying the lps d mutation that renders them unable to respond to bacterial lipopolysaccharide (LPS) – although LPS is only one of multiple stimulators of innate immunity.

One strain that is of great concern to humans is methicillin-resistant S. aureus (MRSA), which is characterized by the presence of a single mutation that renders it resistant to methicillin, a semisynthetic penicillin used to treat staphylococcus infections that are resistant to mold-derived penicillin.

A second mutation that renders UDG defective in nucleotide flipping was then introduced, and the double mutant was rescued using a substrate with a "preflipped" cytosine base.

Most retropseudogenes have undergone extensive mutational decay over evolutionary time, acquiring mutations that render them non-functional, such as large deletions and insertions (including retroelement insertions), frameshifts, and premature termination codons.

For triple combination therapy to be advantageous, most resistant cells must harbor mutations that render them resistant against two of the drugs (but not the third one).

In addition two genes of the putative ABC erythritol transport system, eryF and eryG (BOV_A805 and BOV_A806)) carry mutations that render them pseudogenes (a 2 bp deletion resulting in an premature stop codon).

It is possible that these enzymes contain mutations that render them inactive.

These plasmids encoded MUS81 with conservative mutations that rendered it refractory to siRNAs #9 and #10.