Myriad is known for its test for genetic mutations that indicate a high risk of developing breast and ovarian cancer.
It also developed a test, costing more than $3,000, that examines extracted DNA from the genes for mutations that indicate a woman is at a high risk of getting breast or ovarian cancer.
Please respond to all of these points by revising the manuscript appropriately. 1) The authors now describe mutations that indicate that the binding mode they see is relevant to catalysis.
Among birds they have documented reduced longevity and male fertility, smaller brains, and mutations that indicate significant genetic damage compared with the same species in areas of low radiation.
Standard breakpoints of antimicrobial drugs for H. cinaedi have not been defined, but all isolates in this study had mutations that indicated resistance to macrolides and fluoroquinolones.
[Editors' note: the author responses to the second round of peer review follow.] 1) The authors now describe mutations that indicate that the binding mode they see is relevant to catalysis.
This illustrates that there appears to be no clustering of mutations that would indicate a genotype phenotype correlation analogous to that observed for female breast and ovarian cancer.
Mutations are coloured as in (B ), a horizontal line indicates mutations that have coalesced, * indicates clusters localising within 10 kb of CAN1.
The mutation rate indicates that how many chromosomes out of the total chromosomes undergo the mutation process.
Current mutation data indicates that CNVs in PARK7 are less frequent than simple mutations.
