Sentence examples for mutation restores the from inspiring English sources

Importantly the inhibition of the RAS pathway in cells harboring BRAFV600E mutation restores the LKB1-AMPKα pathway by permitting the re-association of the LKB1-AMPKα complexes.

We further find it exceedingly unlikely that the cdc3 (D210G) mutation restores the ability of Cdc10(D182N) to bind and hydrolyze GTP.

Attractant signaling behavior restored to this mutant by the N53D suppressor mutation restores the wild-type ratio of the two conformer pools and restores the higher kinase activity as shown by the higher dark reversal frequency.

The experiments on the S6′T/I9′L GLIC double-mutant are particularly interesting as the I9′L mutation restores the activity of the channel, suggesting that the residues at positions 6′ and 9′ are paired: S6′/I9′ in GLIC and S6′-T6′/L9′ in all other pLGICs.

While it is not clear how the R23 mutation restores the interaction between the B″ subunit RSA-1 or598 RSA-1 or598 these mutandons likely do not disrupt interactions between PAA-1 and the C. elegans B subunit SUR-6 since the mutations do not phenocopy deplikely of sur-6.

Remarkably, a one-nucleotide mutation within the 5′UAR was correspondingly co-selected; the 5′UAR mutation restored the base pairing with the 3′UAR mutation.

AO therapy could be used in specific CF cases to alter splicing to skip an exon containing a nonsense or frameshift mutation, restoring the reading frame, assuming the resultant isoform retained better function than the mutated protein.

Back mutation restored the colonization ability.

All plants tested were more susceptible than the resistant Kas-1 ecotype and complementation of the atl9 mutation restored the wild-type defense phenotype (data not shown).

The N146A mutation restored the interaction with the complex, while the W155A mutation did not (Fig 3C), indicating that the protruding tryptophan is an essential residue for interaction with the complex.

Notably, the I539T mutation restored the wild-type NBD1 pattern in ΔF508: both protease resistant bands of ∼25 and 27 kDa that had been lost in ΔF508 NBD1 returned upon mutation of I539 to Threonine (Figure 4A, ◂).