Sentence examples for mutation or epigenetic from inspiring English sources

One possibility is that additional genes on 22q (other than NF2 tumor suppressor) are important for meningioma development and these are mutated by alternative mechanisms, such as point mutation or epigenetic silencing.

Protooncogenes can be altered by mutation or epigenetic modification, which converts them into oncogenes and leads to cell transformation.

Additionally, oncogenic activation by mechanisms other than amplification or deletion, like mutation or epigenetic silencing is also important.

The definition of a TSG is based on the demonstration of its regular inactivation by mutation or epigenetic silencing in tumour samples.

Instead this suggests that Myc has been induced or activated in some instances (for example by mutation or epigenetic modification) during the progressive steps to tumourigenesis and has thereby contributed to the development of the lymphoma.

Given the observation that even apparently normal mucosa in patients with HPS is highly methylated [6], we investigated the potential for mutation or epigenetic disruption of DNMT1 (CCDNMT3A8.1), DNMT3B (CCDS1718.1), DNMT3B (CCDS13204.1) and DNMT3L (CCDS13705.1) in the development of HPS.

It has been referred to as the MSI pathway or the mutator phenotype pathway because it is initiated by the mutations or epigenetic methylation of the mis-match repair genes (mostly hMLH1 in chromosome 3p21 and hMSH2 in chromosome 2p16) creating a mutator phenotype to significantly increase the mutation rate of many critical genes 10 to 1000 times.

We found that more than 80% of the colonies were negative for agglutination with this antiserum suggesting that they had stable mutations or epigenetic alterations that eliminated O1 antigen expression.

These stem cells then find themselves in a microenvironment to which they are poorly adapted, providing a competitive advantage to those cells that can restore their functionality and fitness through mutations or epigenetic changes.

Loss-of-function by somatic mutations or epigenetic silencing of KEAP1 impairs its binding to NRF2 and abrogates its repressive effect [159, 166].

Genetic mutations or epigenetic factors that diminish the propensity of a cell to undergo apoptosis may therefore confer on that cell a growth advantage.