Sentence examples for mutation or biochemical from inspiring English sources
This resistance is considered because of emergence through mutation or biochemical changes in the active site of drug targets.
Novel treatments in the drug development pipeline for EOD, such as genetic forms of Alzheimer's disease, should target the specific pathogenic cascade implicated by the mutation or biochemical defect.
Those listed in Table 1 have been shown, by mutation, transgenic manipulation or biochemical analysis, to have defined roles in senescence.
Finally, in some geographic areas mass screening programs for HH based on molecular analysis of the C282Y mutation or on molecular analysis and biochemical marker of iron overload have been performed, in order to prevent disease evolution [ 33].
Here we further investigate the mutator effects conferred by the pol2-Y831A musingon using biochemical and genetic approaches.
Furthermore, if there is a known germline RET mutation (or an unknown mutation status), then biochemical workup to rule out primary hyperparathyroidism and pheochromocytoma is warranted.
In summary, although impairment in intercellular glucose transport through GJs does not necessarily rule out the K+ recycling theory entirely, available data and the new data presented here seem to favor that effects of Cx30 null mutation on biochemical coupling are the major cause for hearing loss observed in these mutant mice.
To ascertain the functional role of this mutation, biochemical studies with the mutant enzyme are needed along with genetic exchange studies in P. falciparum parasites.
The biochemical analyses did not reveal any effect of the K132N mutation on the biochemical phenotype.
Mutation carriers demonstrate biochemical and neuroimaging changes that can precede dementia by 15 years or more and may be used to identify windows of time relative to specific pathophysiologic events in disease [ 4, 15].
Most of these life-extending mutations affect biochemical pathways that respond to nutrient, stress or energy levels.
