Inactivation of condensin subunits by mutation or depletion results in severe morphological aberrations and mechanical sensitivity of metaphase chromosomes, and subsequently to defects in their segregation during anaphase (Hirano and Mitchison, 1994; Ono et al., 2003; Gerlich et al., 2006).
Mice homozygous for this "mPer2Luc" mutation are viable and fertile, with no developmental or morphological differences compared to wild-type littermates.
Strikingly, a transgenic mouse selectively overexpressing two Kir6.2 gain-of-function mutations (an N-terminal deletion of 30 amino acids and a K185Q point mutation; ΔN30,K185Q mice) in the heart showed no gross physiological or morphological cardiac problems [ 30, 31].
or morphological characterization.
Expression of dSpt1 bearing a disease-related mutation induced morphological deficits in synapse growth at the larval neuromuscular junction consistent with a dominant-negative action.
It has been proposed that this difference in abundance of coding and regulatory mutation in morphological characters is due to coding mutations within species not being able to spread through populations due to their pleiotropic deleterious effects [ 17].
A previous study on naturally occurring Hsp83 variants had identified a nonsynonymous deletion mutation in the Hsp83 coding region, and focused on the effects of this mutation on morphological traits, not on fitness components [ 27].
We found no morphological evidence of EMT by molecular markers or morphological alterations.
They found that functional alteration of Hsp90 resulted in transposon activation and the induction of morphological mutants which indicated that Hsp90 mutation or inhibition can generate new genetic variation by transposon-mediated mutagenesis [ 48].
Somewhere among the genetic disparities must lie the mutation or, more probably, mutations that define us.
