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Exact(6)
The parameter vector of the ({text{Child}} = left[ {{text{parC}}_{ 1},cdots cdots, {text{parC}}_{ 2 5} } right]) generated by the mutation is given by {text{parC}}_{text{i}} = {text{parP1}}_{text{i}} + {text{Coe}}_{text{i}}.
The procedure for hill-climbing mutation is given below.
The glucose-sensing threshold for insulin production is upregulated, such that if a person with the GCK mutation is given exogenous insulin, endogenous insulin secretion is lowered so that the glucose is maintained at their homeostatic set point.
For instance,, the probability of a new mutation with fitness effect s being fixed in an otherwise homogeneous diploid population, relative to the probability of fixation of a neutral mutation, is given by (Fisher 1930; Kimura 1957, 1962; Crow and Kimura 1970) (1) where the approximation is valid for small s.
It has been derived that the time period of the k-th mutation is given by (1) t k = k ln s u d 2 2 s ln N where s is the advantageous selection coefficient, u the rate of driver mutations, d the number of sensitively mutated genes, k the number of susceptible genes (potential drivers), and N is the size of cell population.
The probability to increase the fitness due to a new mutation is given by (10) p (W ¯ > d ) = p (W ¯ > d ∣ a > c, b > d ) ︸ 2 θ − θ 2 p (a > c, b > d ) ︸ θ 2 + p (W ¯ > d ∣ a < c, b > d ) ︸ 2 θ − θ 2 p (a < c, b > d ) ︸ θ 2 + p (W ¯ > d ∣ b < d ) ︸ 0 p (b < d ) ︸ 1 − θ = 2 θ 2 − θ 3 In a similar manner, we can calculate the probability to decrease the average fitness due to a new mutation.
Similar(54)
I cannot shake the thought that this mutation was given to me for a reason.
The demographic and clinical characteristics of the breast cancer cases evaluated for the ER mutation are given in Table 1.
It is defined as the proportion of the number of drug-resistant to the number of drug-susceptible strains, so that occurrences of a mutation are given equal emphasis in drug-resistant and drug-susceptible strains.
Genes that when deleted resulted in a synthetically sick phenotype at the permissive temperature when combined with the cdc13 -1 mutation were given the maintenance of telomeric capping (MTC) designation, whereas genes that when deleted synthetically rescued the cdc13 -1 lethality at the nonpermissive temperature were given the rescue of telomeric capping (RTC) designation.
This means that the second branch and the C branch of the PTS have the same overall equilibrium constant: (13) K 1 K 2 K 3 = K 4 K 5, The conditions that results directly from the mutation are given in the headline.
Related(20)
mutation is derived
mutation is involved
move is given
mutation is investigated
relocation is given
transfer is given
transformation is given
mutation is believed
mutation is available
deployments is given
mutation is parametrised
mutation is known
mutation is considered
mutation is done
mutation is inherited
mutation is determined
mutation is linked
mutation is labeled
mutation is implemented
mutation is shown
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com