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The location of a point mutation is determined randomly.
Although the mutated chromosome is identified by a significant shift in allele distribution, the final candidate region containing the mutation is determined by identifying the position of the crossover event in each recombinant progeny.
We define epistasis as a set of genetic interactions where the phenotypic effect of one mutation is determined by the presence of one or more other mutations.
We then introduced mutations following Kimura's (1980) two-parameter model with a preset R. The fixation probability of a mutation is determined jointly by ω1 and ω2.
Since evolution is a random process and each trajectory would represent just one specific case, one would need to observe a large number of such trajectories to illustrate general trends in how the fate of each mutation is determined.
Combining these two facts, we see that, at least in the case of this type of hotspot, the location of mutation is determined combinatorially by the binding of multiple interacting factors, much like the location of transcription is determined in the performing phenotype (writing function is determined much like performing function).
Similar(54)
Presence of the GSTM1 mutation was determined through blood samples.
The factor V Leiden mutation was determined by direct sequencing and the MTHFR genotype by a PCR-based RFLP method.
The LSE1 mutation was determined to be caused by the disruption of a gene encoding α-glucan, water dikinase, OsGWD1 (Os06g0498400; RAP_DB; http://rapdb.dna.affrc.go.jp/).jp/
The amino acid at codon 129 in coupling with the mutation was determined by cloning.
Sex and Ta mutation were determined by PCR-based genotyping [13].
More suggestions(15)
mutation is established
move is determined
mutation is demonstrated
mutation is confirmed
mutation is decided
transfer is determined
mutation is linked
mutation is underlined
mutation is designed
mutation is labeled
mutation is parametrised
mutation is known
mutation is shown
mutation is considered
mutation is done
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