Sentence examples for mutation is causal from inspiring English sources

Phenotype reversion confirms that the Tcf3 mutation is causal for enhanced self-renewal.

The mutation is causal for hemophilia B Leyden [ 5].

However, it's unclear that this missense mutation is causal as the prediction tools are not conclusive (see Table 4).

Identification of this mutation in a homozygous state in ataxic dogs of different, albeit related, breeds supports an earlier assertion [ 10] that this mutation is causal for a neurodegenerative disease that is inherited in an autosomal recessive mode.

Exploiting this possibility, we observed that BAL carries a single SNP located in exon four of the SRS5 gene and demonstrated to be responsible of a small and round seed [ 60], suggesting that this mutation is causal of BAL round grain.

We tested whether the Zfp706 mutation was causal.

The very low frequency (MAF 0.00023) is compatible with this mutation being causal of a rare phenotype like JATD with a disease prevalence of less than 1 100 000.

5q22.2 notably contains the APC gene and suggested the possibility of a non-coding APC mutation being causal in this FAP kindred.

In other words, if a given mutant strain contains 100 mutations relative to the parent, we assume that only one of those mutations is causal (i.e. needs to be in a true target gene).

DOI: http://dx.doi.org/10.7554/eLife.04279.010 Repeated mutations to the same loci in independently evolved replicates strongly suggested that the mutations were causal.

The link between ETC abnormalities, apoptosis, fiber atrophy, and necrosis supports the hypothesis that mitochondrial DNA deletion mutations are causal in myofiber loss.