Sentence examples for mutation increasing the from inspiring English sources

BRAF is mutated in more than 50% of all melanomas, with BRAFV600E being the predominant mutation, increasing the protein's kinase activity and, thereby, driving downstream cellular proliferation through the MAPK pathway [4].

"Every species leap [by H5N1] represents a new virus mutation, increasing the chance that one will become highly infectious to humans," says Dr Peter Horby, an epidemiologist at the World Health Organisation (WHO), in Hanoi.

But functional studies from two groups show that the putative causative allele is a gain-of-function mutation increasing the expression driven from the lactase promoter in reporter gene assays in a human intestinal cell line.14, 15 So what about the second reason – a different causative mutation in Africans?

The DARPin not bearing the residue 52 mutation has an unusually slow on-rate, suggesting that binding occurred via conformational selection of a relatively rare state, which was stabilized by this His52Tyr mutation, increasing the on-rate again to typical values.

She was also identified as a carrier of the gene mutation increasing the risk of developing the disease.

No such lumps showed up in the brain tissue of healthy controls or ALS and FTD patients without the C9orf72 mutation, increasing the likelihood that the mutation produced them, Dieter Edbauer, a molecular biologist at Ludwig Maximilians, and his co-authors report online today in Science.

α is the multiplicative factor by which a mutator mutation increases the somatic mutation rate per cell generation, e.g. the magnitude of the genetic instability.

The N15D mutation increased the thermal stability of VPR by ∼ 3 °C, both in T50% and Tm.

Conversely, the T202C mutation increased the flexibility of loop A, enhancing the catalytic efficiency beyond that of the native enzyme.

The E22Q mutation increases the population with intact VGSN turn compared to the wild-type (WT) peptide.

The deletion mutation increased the sucrose consumption rate significantly when sucrose or sugarcane molasses was used as a carbon source.