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Exact(5)
The D175N mutation has shown no change in stability and is therefore not predicted to alter flexibility.
BRAF mutation has shown promising results in predicting prognosis in conventional PTC, however its prevalence is distinctly lower (18%) in PTMC smaller than 5mm in diameter [ 20].
However, resistance to these drugs is still possible, as a recombinant H3N2 virus containing the E276D mutation has shown resistance to both zanamivir and oseltamivir in one study.
One study on a large Utah-based kindred with an identified BRCA1 mutation has shown that female gene carriers' intentions to have more children were lower than those of noncarriers, but not significantly so.
Analysis of animals homozygous for the Lhx6 mutation has shown a similar number of GABA-positive interneurons in the neocortex, but lacking the PV and SST subpopulations (Liodis et al., 2007).
Similar(55)
On the other hand our investigation of the cells from heterozygous carriers of the p.I171V, c.657del5 and p.R215W mutation has showed that alone, they do not play an essential role in carcinogenesis [ 36].
Genetic mapping of das13 (one of the das mutations) has shown it to be in the region of the rnh gene encoding RNase H.
However, evaluation of telomere lengths of DNA samples of following generations of TERT mutations has shown a statistical trend toward further telomere shortening for three large kindreds.
Analysis of the ability of this microarray to detect known gene mutations has shown a 97% mutation detection rate for base substitutions.
Recently, a drug class called poly ADP ribose polymerase (PARP) inhibitors that targets cancers caused by BRCA mutations have shown promise in clinical trials treating breast cancer [52].
The mitochondrial protease OMI (also known as HtrA2) has been implicated in Parkinson's Disease (PD) and deletion or protease domain point mutations have shown profound neuropathologies in mice.
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Justyna Jupowicz-Kozak
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