Sentence examples for mutagenesis has shown from inspiring English sources

In the native sequence only period 1 (P1) and period 5 (P5) of the seven proposed periodic sites have destabilizing Ala clusters within the consensus region; deletion mutagenesis has shown these regions contribute the most to cooperative actin binding [20], [35].

Site-directed mutagenesis has shown that several residues are required for AOX activity [ 44].

The natural capability of microorganisms to produce amylases has also been successfully improved using mutational treatment, where both UV and chemical mutagenesis has shown to enhance amylase production.

Mutagenesis has shown that this three-residue motif is necessary for both depolymerization and microtubule-stimulated ATPase activity of the Plasmodium MCAK (Shipley et al, 2004) and Xenopus MCAK (Ems-McClung et al, 2007).

Since site-directed mutagenesis has shown that a Tyr to Phe substitution in the heterologously expressed vertebrate α7 subunit results in a tenfold lower affinity for ACh [ 42], Tcasα9 may have unusual ligand binding properties.

This arrangement is known not to impair termination as, for example, in the E. coli thr operon attenuator, the terminator features a GC-rich stem-loop flanked by 9 Us at the 3'-, and 6 As at the 5'-end, and site-directed mutagenesis has shown that upstream adenines are neither essential, nor detrimental to transcription termination [ 41].

Systematic studies on mutagenesis have shown that only Leu438 and Ala439 have the ability to tolerate mutations.

Efforts to re-engineer BcII through mutagenesis have shown similar variability in the position of Zn2, with dramatic effects on the reactivity of the resulting enzymes.

Among the seven quasi-equivalent periods in 284-residue tropomyosins (P1-P7), a series of mutagenesis experiments has shown that those with destabilizing Ala clusters (P1 and P5) are the most critical for actin binding.

The mutagenesis study has shown that the Tyr residue is not required for the generation of the reaction intermediate but for protonation of it to generate the product HP.

Of note is that in the absence of inflammation, T cells play no protective role by recognizing spontaneously mutated proteins, because a recent study using mutagenesis via a retrotransposition has shown that the adaptive immune system does not suppress spontaneously developing tumors [ 44].