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Exact(5)

Thus, the MSCs with homozygous or heterozygous LMNA mutation generated in our study also provide opportunities to investigate the role of progerin in a dose-dependent manner.

Figure 2 illustrates the mapping results for a lethal mutation generated in our EMS screen, psg24.

A scheme of the mutation generated in the nodD3, nodD4 and nodD5 genes are shown in Fig.  1.

This led us to conclude that the second mutation generated in the TK2 domain (Y823D) was responsible for the loss of sensitivity to imatinib in the metastatic tumours.

The GRE1 mutant (853 bp upstream from the translation start site) resulted from a point mutation generated in pGL4400 by PCR with 5′TGGAAGGGCGTCC(T A(C TGGA3′ used as the primer.

Similar(55)

The mutations generated in the malaria mutator were probably generated during natural processes of DNA replication as the principle of the mutator relies on a defective proofreading activity of DNA polymerase δ.

Recurrent mutations generated in each network are summarized in Table S1.

Recently, stk1 mutations generated in S. aureus strain SH1000 showed attenuated virulence which was attributed to purine auxotrophy [72], [86].

The mutations generated in the kinase domain were confirmed by sequencing from both directions.

A large number of knockout or reduced function mutations generated in the laboratory also show such facultative cheating behavior [ 21].

We reconstructed ∼86 95% sequence regions that encompassed the 14 chromosomes and analysed them for mutations generated in PbMut and PbCtl.

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