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The discovery of mutated genes in human cancers and the patterns behind the mutation data have provided critical insights into the mechanisms underlying cancer formation and development, and have proven helpful for cancer therapy [3], [12].
GPCR mutation data have been primarily collected from GPCRDB [ 13].
Other sources of mutation data have been considered including HGMD and SwissProt Variants (SwissVar).
Correlated mutation data have enabled the generation of pairwise amino acid contact maps from sequence data (Marks et al., 2011; Nugent and Jones, 2012).
Finally, p53 mutation data have also been used to predict the poor response of Barrett's tumour patients to photodynamic therapy (Krishnadath et al, 2000).
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In addition, we sequenced PIK3R1 and TSC2 as no mutation data has been published for these two genes in UC.
6.The authors could indicate catalytic residues explicitly (although mutation data has been mapped) in the figure 1A.
This lack of p53 mutation data has led to controversy with respect to the timing of p53 mutation in Barrett's progression (Fitzgerald and Triadafilopoulos, 1998).
Over the past 15 years only a minority of the published studies which have attempted to correlate mutational and IQ data have reported mutations across the full mutation spectrum seen in the DMD gene [1], [26], [32] [36].
Despite infrequent inactivation in many cancers, mutation and functional data have established that KDM6A is a bona fide tumor suppressor gene.
Interestingly, FLI1 module has been captured by FuseNet when fusing RNA-sequencing and mutation data but has been missed when using FuseNet with any of the two cancer datasets in isolation, as well as by any other inference algorithm considered in this study.
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