Sentence examples for mutation studies have from inspiring English sources

Recently, mutation studies have been reported that have shown that a certain degree of viral resistance to diketo acids (DKAs) appears when some amino acid residues of the IN active site are mutated.

Point mutation studies have shown that residues His134 and His166 of HmuY are involved in six-coordinate binding of haem [10].

Yet neither linkage analyses or mutation studies have provided supporting evidence for these studies.

The BRCA1 and BRCA2 mutation studies have been performed in the Anglia, British, Scottish, Welsh, and Irish populations (Table 3).

Unlike with IHC biomarkers, where NSCLC subtype has largely been ignored, mutation studies have demonstrated prognostic effects for some mutations which are mostly found in lung adenocarcinomas.

Although in vitro mutation studies have not been reported for ABD2, missense mutations in actin-binding domain 1 (ABD1) can cause protein instability, misfolding and aggregation [ 31, 32], leading to a reduction of expressed protein.

Most of the other mutations studied have only been observed in low numbers of PD patients and further work is required to assess the contributions these mutations make to the development of disease [ 6].

Previous deletion mutations study has suggested that the GNE kinase domain is responsible for dimerization, while a segment of residues between the epimerase and kinase domains, residues 360 382, is a potential site for trimerization [18].

Clearly, the set of mutations studied has a high potential for protein multi-feature modulation, as is dramatically illustrated by the combination of stability enhancement and eukaryotic signature of catalysis we describe below.

Previous mutation screening studies have indicated that mis-sense mutations in the ATM gene – rather than protein-truncating mutations – are over-represented in patients with breast cancer compared with the general population [ 72, 75- 79].

Presumably owing to the insufficient number of cases per mutation, previous studies have focused on the comparisons between wild-type and mutant p53, or between large categories of p53 mutants.