Sentence examples for mutation cell lines from inspiring English sources

Methods: One glioblastoma (U-87 MG) and four NSCLC (erlotinib-sensitive HCC827, erlotinib-resistant HCC827, gefitinib-resistant HCC827, and erlotinib-resistant HCC827 with a secondary EGFR mutation) cell lines were incubated with 11C-erlotinib up to 60 min.

Thus the differentiation of heterozygous GBA mutation cell lines into Parkinson's disease and non-manifesting carrier cell lines is artificial.

Interestingly, the promoter mutation cell lines carrying the −124C/T mutation had elevated levels of TERT mRNA expression, without a equivalent increase in telomerase activity.

Zinc, for example, has been suggested as it re-establishes chemo sensitivity in breast cancer SKBR3 (expressing R175H mutation) and glioblastoma U373MG (expressing R273H mutation) cell lines to adriamycin and cisplatin treatment, respectively [ 23].

Ambroxol hydrochloride increases glucosylceramidase activity in control, Gaucher disease and Parkinson's disease with GBA mutation cell lines, by activating components of the CLEAR network through TFEB combined with chaperone activity (Supplementary Fig. 2).

We extracted DNA from a lymphoblastoid cell line derived from an affected individual carrying the PRPF31 c.1347+654C>G mutation (cell line #13189) and amplified the 31-kb NDUFA3-PRPF31 genomic region by 4 individually-amplified long-range PCR, designed as previously described [4] (Fig. 1).

Because cells in the lining form islands with oligoclonal expansion of individual mutations, cell lines derived from a different fragment of synovium would be expected to have different mutations compared with another region.

12– 14 We investigated phenylbutyrate in four cell lines from patients harboring PDHB mutations (cell lines 24 27, Table 1) including the p.M101V mutation, and three of them showed a statistically significant increase in PDHC activity after phenylbutyrate incubation (Fig. 3A).

As Ras activation is likely to promote tumor cell proliferation to assess whether successful inhibition of the EGFR signaling pathway is associated with KRAS mutations cell lines were examined for KRAS gene mutations.

As a positive control for mutation of the TP53 gene, genomic DNA of NCI-H23 (codon 246 mutation) and MIA PaCa-2 (codon 248 mutation) cancer cell lines were used.

MuGex [ 5] uses 12 regular expressions to detect mutations and statistical techniques to disambiguate between protein mutations and nucleotide mutations or cell lines.