It also inhibits the proliferation of EZH2 mutant cell lines and the growth of EZH2 mutant xenografts in mice.
By combining TSC1 or TSC2 mutant cell lines with RNAi screens against all kinases and phosphatases, we identified synthetic interactions with TSC1 and TSC2.
These mutant cell lines may provide a useful system for isolating, expressing, and exploring the functions of genes involved in capacitative Ca2+ entry.
The anti-proliferative effect of all synthesized compounds against gefitinib insensitive double mutant cell lines Ba/F3 expressing Del19/T790M and Ba/F3 expressing L858R/T790M were assayed.
Pathway analysis of the differentially expressed proteins demonstrated strong associations with neurological disorders, muscular and skeletal disorders, and cardiovascular diseases in the cblC mutant cell lines.
In CD45 mutant cell lines, CD45-deficient mice and CD45-deficient human SCID patients, CD45 is required for signal transduction through antigen receptors.
In these cases, releasing the code may not be a requirement for publication, but such custom-developed software will often be as important for the replication of the procedure as plasmids or mutant cell lines.
The Drosophila RNAi Screening Center (DRSC) is collaborating with the Simcox Lab (Ohio State Univesrity) and the Bellen Lab (Baylor College of Medicine) to make new cell lines, knockout mutant cell lines, and knock-in GFP-tagged cell lines.
Global lipidomics applying the shotgun procedure was instrumental in identifying the defect in GPI-anchor biosynthesis in mutant cell lines lacking the TbGPI12 gene in procyclic trypanosomes [17].
Normal ovarian epithelial cells and two ovarian cancer cell lines with wild-type p53 expressed readily detectable levels of p21, whereas in p53 null and mutant cell lines, expression of p21 was diminished strikingly.
Six mutant cell lines were investigated.
