Sentence examples for mutation and genomic from inspiring English sources

The rapidity by which the landscape of mutation and genomic changes is being identified also has led to a new paradigm and approaches to pathological diagnosis of NSCLC.

With the high correlation of TP53 mutation and genomic instability in ESCC, the amplification of CCND1, the deletion of CDKN2A/2B, and the somatic mutation of TP53 appear to play pivotal roles via G1 deregulation and therefore helps to classify this cancer into different genomic subtypes.

ZAP-70 status, IgVH mutation, and genomic aberrations were determined as described in Methods S1.

Mutation and genomic instability provide tumours with sufficient diversity, so that cells with adaptive and proliferative selective advantage can evolve in a Darwinian manner.

Our study showed how they differed in progression-related characteristics, such as tumor grade, p53 mutation and genomic instability.

Liu et al. [ 35] revealed that the down-regulation reported in cancer be driven by promoter methylation, mutation, and genomic deletion of the NDRG2 gene.

DHX9 is able to bind to intramolecular triplex DNA, hot-spots of mutations in human genome, and to prevent mutations and genomic instability, probably by acting on DNA structure [ 32].

There is increasing evidence that autism spectrum disorders (ASDs) can arise from rare highly penetrant mutations and genomic imbalances.

Understanding the driving mutations and genomic landscape of DIPGs can now guide the development of targeted therapies for this incurable childhood cancer.

Frequent distribution of short non-parental segments could be due to a combination of factors such as structural variants between Nipponbare and the parental lines, de novo mutations and genomic alterations at the chromosomal level.

Recent studies suggest that proto-oncogenes exert regulatory effects on metabolism in normal cells, and that tumorigenic mutations and genomic amplification of these genes contribute to the metabolic autonomy observed in tumor cells [7].