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Exact(6)
The dynamics of cells include the following events: a faithful cell division (such that both daughter cells are of the original type), a division with a mutation, and cell death (other events such as cellular quiescence and awakening from the state of quiescence could also be included, see [62], [63]).
Exposure to DNA damaging agents can cause mutation and cell death and may ultimately lead to disease.
During chronic inflammation, locally produced ROS and RNS can attack DNA to cause mutation and cell death as part of the pathophysiology of cancer and other diseases.
DNA damage is constantly generated from endogenous and exogenous sources in cells and poses a major obstacle to vital cellular processes of replication and transcription, possibly leading to mutation and cell death.
ABSOLUTE [ 22] was used to estimate sample purity and ploidy and then calculate cancer cell fraction (inferred percentage of neoplastic nuclei that harbor a given mutation) and cell copy number of mutations and local DNA copy changes.
Consequently, BrdU is a toxic mutagenic substance and can cause abnormalities in DNA transcription and protein translation, which could lead to mutation and cell toxicity, compromising the overall health and behavior of the organisms, both in fetal and in postdevelopmental stages [ 14– 16].
Similar(54)
Tbx1 also functions during pharyngeal segmentation, which has been established by timed mutation and cell-fate mapping experiments and is expressed in a rostro-caudal gradient following the direction of pharyngeal segmentation (59, 77).
Goranova et al. showed samples presenting: neoplastic cells with P53 mutation, and cells showing APC and/or K-Ras mutation but not P53 mutation [ 6].
Further, the mean migrating distance of cells with mitND6 gene nonsense mutation and cells treated with rotenone was similar and was significantly longer than cells with mitND6 gene missense mutation.
Further, cells with mitochondrial ND6 gene nonsense mutation and cells treated with rotenone showed significantly higher cellular ROS level than cells with mitochondrial ND6 gene missense mutation, while there was no significantly difference between the last 2 groups.
But, she found, D.C.I.S. cells looked just like cells from aggressive breast cancers — gene expression patterns, mutations and cell maturation patterns were all the same.
Related(16)
abnormality and cell
transformation and cell
transfer and cell
move and cell
relocation and cell
transfers and cell
mutation and screening
mutation and speciation
mutation and survival
mutation and elitism
mutation and crossover
mutation and cross-over
mutation and migration
mutation and selection
mutation and recombination
mutagenesis and cell
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