Sentence examples for mutation activates the from inspiring English sources

For example, oncogenic activation of the RAS genes by point mutation activates the pathway via the interaction of RAS with p110α, the catalytic subunit of PI3 kinase [ 10].

Each mutation activates the same three cryptic splice sites.

We demonstrated that V617F mutation activates the JAK2-STAT5 pandway, and induces cytokine-independent growth in Ba/F3 cells without expression of the erythropoietin receptor.

Therefore, the APC mutation activates the Wnt signal pathway and mediates an increase in miR-224, which may serve as a negative regulator of cell motility and metastasis.

The hypothesis is that KRAS mutation activates the RAS/MAPK signaling pathway downstream of EGFR independently of ligand binding to the receptor.

Altogether, these data suggested that the c.903+469T>C mutation activates the pseudoexon by strengthening and/or creating an ESE, which potentially could function by binding of the splicing factor SF2/ASF.

We recently established that human fibroblasts harboring the ATPase 6 NARP mutation activated the Nrf2-dependent Phase II antioxidant pathway [24].

Furthermore, activation of receptor tyrosine kinase (RTK) signaling by either the ligand or by a mutation activating the receptor constitutively leads to EMT [ 7].

Leucine-rich repeat kinase 2 (LRRK2) is mutated in familial Parkinson's disease, and pathogenic mutations activate the kinase activity.

Mutations activating the N-RAS or B-RAF kinase components of the mitogen-activated protein kinase (MAPK) pathway are found in approximately 15% and 60% of human melanomas, respectively [ 3- 5].

Cheung, L.W. et al. Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors.