Sentence examples for mutant activates the from inspiring English sources

They demonstrated that hyperactive forms of Msb2p and Hkr1p can activate the HOG pathway only in the presence of Sho1p, whereas a hyperactive Sho1p mutant activates the HOG pathway in the absence of both Msb2p and Hkr1p, indicating that Msb2p and Hkr1p are the most upstream elements in the Sho1p branch [ 47].

It is puzzling that the mutant activates the GLX shunt, which is mostly associated with growth on two-carbon substrates, and generates one net OAA from acetyl-CoA without any energy conservation.

The R337H mutant activated the reporter as efficiently as wild-type p53 did.

Mutational analysis indicated that wt Vpr, but not cell cycle inactive Vpr mutants, activated the p21 promoter.

All of the mutants activate the conventional PDGFRα signalling pathways.

Importantly, WT and both mutants activated the #325 gene to similar extends.

Furthermore, transfection of cells with RasV12, a constitutively active Ras mutant, which activates the ERK pathway, is sufficient to promote miR-29a, miR-29b, miR-221 and miR-222 overexpression without the addition of EGF.

In addition, during growth, the K3 mutant activates a generalized stress response adaptation.

Interestingly, whereas the MT1-G166E MT1-I212T212T mutappearppear to be biased towards the ERK1/2 pathway, the MT2-V124I mutant (mutation located in TM3) appears to be biased towards the cAMP pathway, as this mutant fully activates the cAMP pathway, but only partially the ERK1/2 pathway.

The G-V curves for the channels mSlo1/β4, mSlo1/β4(G63A), mSlo1/β4 (H105A), mSlo1/β4(H153andand mSlo1/β4(D166R) are not statistically different from that of the wild-type (WT) mSlo1 alone channel at 10 μM Ca2+, whereas β4 mutant N123A activates the channel by significantly shifting the channel G-V curve to more negative voltages (Fig. 5a).

An active mutant of TRAF4 activates the NADPH oxidase downstream from the Rho GTPases and PAK1 and oxidatively inactivates PTP-PEST.