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This is particularly the case, if viral mutants, which carry resistance against all (or at least the majority of) drugs in the maintenance combination, are archived in the latent reservoir prior to treatment initiation.
The pattern in met-1 mutants, which carry only MES-4-dependent H3K36 methylation activity, is strikingly different.
We examined lungs taken from two mouse mutants which carry loss of function mutations affecting the following proteins: Celsr1 (crash, Crsh) and Vangl2 (loop-tail, Lp) (26– 30).
Knockdown of PHB genes extends the lifespan of gas-1 mutants which carry a lesion in the 49-kDa iron-sulphur subunit of complex I of the ETC.
These studies resulted in identification of new sis mutants which carry defects in the ABA biosynthesis gene NCED3/STO1 or the ABA response gene ABI3.
We began by imaging kdrl y17 mutants, which carry a mutation in one of the zebrafish Vegf receptor-2 orthologs, previously shown to result in arterial-specific defects (Covassin et al., 2006).
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The dsetdb1G19561 mutant, which carries an EP element [33] inserted at a position 60 nucleotides downstream of the dsetdb1 translation initiation site, was obtained from GenExel.
However, the mir168a-2 mutant, which carries only a MIR168b locus, does not develop normally when stressed in a glasshouse, suggesting a role for MIR168a during stress adaptation.
The SeV Cm mutant, which carries a mutated C protein, and the V-mutant, which lacks the V protein, were used because these viral accessory proteins suppress IFN responses [37], [38].
The AtELP1 mutant, which carries a T-DNA insertion in the third exon of At5g13680, similar to the previously identified elo2 mutant[ 46] showed no detectable ncmU.
The FLAG-Parkin(R42P) mutant, which carries a mutation in Parkin's Ubl domain, was expressed at levels similar to Parkin WT), but showed a tendency to misfold.
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Justyna Jupowicz-Kozak
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