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Such structures may interfere with replication fork progression [75] suggesting a possible mechanism for cell progression defects that extend into S phase in these mutants when exposed to DOX.
Despite this difference, control animals exhibited significantly higher total cysteine levels compared with mutants when exposed to galactose plus paraquat (P=0.0003; Fig. 6B).
Therefore, we investigated whether knockdown of VE-cadherin, a major component of endothelial cell-cell adhesion complexes, affects the bleeding tendency in tie-2 mutants when exposed to atorvastatin.
Chl a, b and carotenoid contents were strongly decreased in leaves of the vtc2-1 mutants when exposed to a light intensity of 300 μmol m-2 s-1 (21%, 20%, and 20%, respectively), 700 μmol m-2 s-1 (38%, 35%, and 33%, respectively), and 1,500 μmol m-2 s-1 (44%, 45%and32%2%, respectively) and compared to vtc2-1 mutants raised at control conditions.
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The thermoresistance phenotype of atx-3-null animals was independent of the HSF-1 transcriptionfactor, sincehsf-1; atx-3 double-mutants behaved as atx-3 single-mutants when exposed to a 5 h heat shock (Figure 7A, B).
To ascertain the role of trehalose in C. albicans apoptosis, we compared the apoptosis rate between the wild-type cells and tps1Δ mutant when exposed to different concentrations of H2O2.
Chloroplast size was significantly lower in the wildtype, the pad2-1 and vtc2-1 mutant when exposed to light conditions and compared to the same plants exposed to control conditions.
All three nuclease domain mutants, Fan1-D651A, Fand-E666Q Fan1-K668A668A, phenocopied the pso2 fan1 double null mutant when exposed to either UV or cisplatin (Fig. 2C).
Plastoglobuli contents were significantly increased in the wildtype (up to 88%), the pad2-1 (up to 131%) and the vtc2-1 (up to 223%) mutant when exposed to high light conditions.
These genes were filtered out during analysis because the single mutant was inviable when exposed to 4 µg/ml CPT.
To test this hypothesis, IAA production was quantified in R. leucaenae CFN 299 and in its 200-kb pSym deleted mutant CFN 299 10 when exposed to various flavonoids.
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