Sentence examples for mutants it seems from inspiring English sources

From the above experiments on brain mRNA from SAP102 and PSD-95 mutants it seems likely that these effects of genes linked to the mutant allele might be generally important in other knockout lines and other tissues.

In contrast, we have found many autophosphorylation sites of TRPM7 basally phosphorylated in mammalian cells and in combination with our in vitro analysis of TRPM7 mutants, it seems unlikely that the TRPM7 S1512A/S1568A mutant would have significantly reduced incorporation of phosphate in living cells.

However, as VEGF inhibition reduces angiogenesis in vhl mutants, it seems likely the abnormal angiogenesis seen in these mutants is predominantly driven by hypoxic signalling, rather than by increased blood flow.

Since the current manuscript does not use BiFC or FRET to characterize formation of heteromers between MGAT1 and these inactive GNT1IP-L mutants, it seems premature to conclude that specific sub-regions of the lumenal domain are required for GNT1IP-L inhibitory activity.

Overall, based on the results for Libri et al.'s [ 8] and Charpentier and Rosbash's [ 9] mutants it seems that, at least for RPS17B intron, base-pair probabilities for the two base-pairs formed between the first two bases of the intron and the second and third base of the branchpoint sequence are good indicators of splicing efficiency.

Because, by contrast, the overall frequency of autophagosomal organelles was notably increased in the mutant, it seems probable that the autophagic process in p35 mutants was disrupted at some later stage, although testing this will require further study.

For the G37R mutant, it seems unlikely that the WT protein would be able to stabilize mutant SOD1 protein to a sufficient degree to increase the levels of the mutant protein by more than 2-fold as would be required to explain why co-expression of the WT protein in G37R mice causes paralysis earlier than observed in the homozygous G37R mice.

On these grounds, and taking into account the range of genetic defects and properties of the R mutants tested, it seems unlikely that any R vaccine lacking the ability to induce anti S-LPS antibodies could match classical brucellosis vaccines in the natural host.

The significance of this is unclear (see Discussion), but, as these regions are not mis-expressed in DSas-6 mutant cells, it seems unlikely that these changes are a direct result of the lack of centrosomes in DSas-4 mutants.

Although we cannot exclude the possibility of subtle differences in the assembly or dynamics of actin and microtubules between wild-type and mutant strains, it seems that the actin- and microtubule-cytoskeletons were unrelated to Sep4 fibers.

Although we have not experimentally analyzed the expression of the mutant COL6A1 gene, it seems likely that the mutant transcripts will be subject to nonsense-mediated decay and that the COL6A1 c.289G>T variant leads to a true null allele of the COL6A1 gene.