Sentence examples for mutants it remains from inspiring English sources

While experiments in broth culture indicate a competitive fitness defect for prfA* mutants, it remains possible that PrfA activation contributes to L. monocytogenes outside of mammalian infection, for example by promoting bacterial survival in the presence of lower eukaryotes or other soil dwellers.

In light of the unusual behavior displayed by certain CL mutants, it remains to be determined which previous findings are applicable to kinesin in its WT form.

While we have confirmed the RNAi phenotypes for a small number of genes using independent RNAi lines and mutants, it remains possible that some of the genes identified are false positives due to off-target effects of RNAi.

Our data show a significant elevated expression of ALDH1A1 in the middle aged mutant and although it decreases in the aged mutant, it remains ~2.5-fold higher than its age-matched control.

Although we find Mad2 dimerization apparently intact in the Mad1-EDD/QNN, Mad1-Δhelix or Mad1-RLK/AAA mutant (Fig 3), it remains possible that these regions are involved in promoting the conformational change of Mad2 that is required for binding of free Mad2 to Cdc20 [ 28, 29] (Fig 4B).

A particularly striking feature of HD pathology and genetic models is the aggregation of mutant HTT protein, but it remains unknown how aggregates contribute to toxicity in this diseases.

However, as we lacked data on the expression levels and subcellular localization of the mutant proteins in affected tissues, it remains unclear whether accelerated gating per se causes the human pathology.

However, it remains uncertain whether mutant p53 acts in a dominant negative fashion over the wild-type protein.

Therefore, it remains controversial whether mutant CFTR itself causes ER stress, UPR induction and subsequent inflammation or whether the chronic inflammation observed in CF is the primary ER stress effector leading to UPR activation independent of the aberrantly folded CFTR.

However it remains unknown if mutant FUS dysregulates autophagy in ALS.

It remains possible that the mutants lacking the ECD inhibit adhesion through a dominant negative mechanism involving the endogenous full length Trask and its ECD.