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In addition to the full-length transcript, mutants in components of the Set2-Rpd3S pathave have cryptic internally initiated transcripts [5], [6], [7].
Mutants in components of this cascade are severely affected in their ability to infect corn plants.
It is possible that 33° was also too stringent to recover mutants in components of the Set1 protein methylation complex that methylates Dam1, which were previously shown to suppress ipl1 -2 (Zhang et al. 2005; Latham et al. 2011).
In addition to three intragenic suppressors of ipl1 -2, our classical genetic screen identified new alleles in previously identified components of the Glc7/PP1 pathway (GLC7, YPI1, SDS22, and SHP1 ), a component of the TORC1 complex (TCO89 ) and two mutants in components of the outer kinetochore (DUO1 and NDC80 ).
We identified heterozygous deletion mutants in components of the small (RPS) and large (RPL) ribosomal subunits; the ribosomal stalk (RPP1B ); and components of the mitochondrial small (MRPS, PET123, RSM) and large (MRPL) ribosomal subunits, as well as proteins involved in ribosome biogenesis (DBP9, RRP15, RSA3 ).
Subsequent experiments with null mutants in components of the Hh pathway in zebrafish and mouse have raised questions about the conservation of the mechanisms of Hh signal transuction during evolution, and have suggested that utilization of the primary cilium for signaling might be a mammalian innovation.
Similar(54)
Given the radiation-sensitive phenotype displayed by mutants defective in components of the NHEJ pathway, in multiple eukaryotic species, we reasoned that these proteins were good candidates for screening for abnormalities in radiation-sensitive cancer patients.
Mutants in polarisome components and the myosin V motor protein resulted in reduced efficiency of segregation of protein aggregates and lowered replicative lifespan.
Mutants in different components of the osk mRNA localization complex produce very similar phenotypes when analyzed by in situ hybridizations to fixed samples.
This study reports the results of the first genetic investigation of the pattern of oscillations of intracellular NADH of single deletion mutants in key components of the glycolysis pathway in S. cerevisiae.
Mutants in another component of the RNA export machinery, AtNUP160 (the Arabidopsis ortholog of the NUP160 subunit of the nucleoporin NUP107-160 subcomplex), are also sensitive to chilling and freezing stress [42].
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