Sentence examples for variants in components from inspiring English sources

One can envision a future whereby comprehensive assessment of genetic variants in components of drug pathways for all approved anticancer drugs will be conducted at diagnosis.

Bcat mice are therefore likely to provide a background that is genetically sensitized for the functional detection and confirmation of mutation variants in components of the canonical Wnt/β-catenin pathway.

Population-based association studies have identified genetic variants in different components of TGF-β signalling to be associated with OA.

We predict that the remaining unexplained forms of MMHIS are caused by variants in other components of this apparatus.

Many other studies have examined genetic variants in key components of immune and inflammatory pathways known to be activated in this disease.

Besides a strong association of GCA with genes that lie within the major histocompatibility complex (MHC) [ 16- 21], many other studies have shown the implication of genetic variants in key components of immune and inflammatory pathways in GCA susceptibility or clinical expression of this vasculitis [ 21- 34].

The structure of 1 bears a close similarity to that of its di- tert-butyl variant 2. In component connectivity they are identical.

Such differences may be the result of tissue or cell line-specific variants in either the components of the ubiquitin proteasome pathway or in their modification by intracellular oxidants or reductants.

Therefore, given the pivotal role of TLR signaling pathways and their negative regulators in the development of sepsis, we hypothesized that variants in genes encoding components of the TLR signaling pathways and their negative regulators might confer susceptibility to sepsis.

This task was partly tackled by Gold et al. [60] who found ARM-associated variants in the complement component receptor B (CFB, GeneID 629) gene and the adjacent complement component 2 (C2, GeneID 717) gene on chromosome 6p21.

The genetic space occupied by the variants of a given component will likely be explored very rapidly via single mutations starting from any variant in each component.