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For the C266A, C266M and C266A/L268A mutants a significant reduction in the overall hydride transfer (HT) rates was observed along with the absence of charge-transfer complex formation.

For all mutants, a significant fraction of the individuals manage to clear the virus, fully or in part.

Importantly, in dystrophin/utrophin double mutants, a significant amount of Dg remains at the synapse, indicating that other proteins control, in parallel, its synaptic localization [54], [55].

Whereas βPS integrin was indeed found at attachment sites in ΔC3GMS mutants, a significant amount could also be detected throughout the muscle fibers, rather than being concentrated exclusively at the muscle-muscle and muscle-epidermis attachment sites.

In engulfment-deficient mutants, a significant fraction of those cells survive and remain alive during adulthood (Supplementary Figure S7).

Consistent with filopodia results, we recorded in adolescent Lis1 +/− mutants a significant decrease in spine elimination over 48 h (Lis1 +/+ : 9.3 ± 2%, Lis1 +/− : 3.3 ± 0.9%), a significant increase in stability (Lis1 +/+ : 90.7 ± 2%, Lis1 +/− : 96.7 ± 0.9%) and no difference in formation rates (Lis1 +/+ : 4.3 ± 3%, Lis1 +/− : 5.4 ± 1.3%; Fig. 1E).

Similar(54)

In the leaves of the gln1.3 mutant, a significant increase was observed in the content of a number of organic acids involved in the tricarboxylic acid (TCA) cycle, notably malate, 2-oxoglutarate, fumarate and aconitate.

Indeed, as compared with rats fed with Nissle WT, we observed in rats fed with Nissle Δ clbA mutant a significant worsened body weight gain concomitant with enhanced colitis score and MPO activity.

Like Nrp2 taugfp/taugfp mutants, Sema3f −/− mutants, but not Sema3g lacZ/lacZ mutants, exhibited a significant increase in LEC number (Fig. 3B′ vs D′ vs E′; H).

In addition to all previously known pex mutants defective in PTS1 protein import, mdh2 and afg1 deletion mutants showed a significant amount of cytosolic GFP-PTS1 as well.

Our data demonstrate that Lp mutants exhibit a significant decrease in axis length compared to wildtype embryos and Shroom3/Lp double mutants exhibit a further decrease compared to Lp mutants (Fig. 1J).

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