Sentence examples for mutant models of from inspiring English sources

Deep sequencing of the different mutant models of DM1 will be very useful in generating and further refining genotype/phenotype relationships.

Taken together, our results demonstrated that a combined treatment with IMO and everolimus is effective in VHL wild-type and mutant models of RCC by interfering with both cancer cells and microenvironment.

A combined treatment with everolimus and IMO is effective in VHL wild-type and mutant models of RCC by interfering with tumour growth and angiogenesis, thus representing a potentially effective, rationale-based combination to be translated in the clinical setting.

Given the recent dramatic rise in the development of new mouse mutant models of neurological disease, it is imperative that additional discriminative tests are developed to investigate motor deficits in these mice as comprehensively as possible.

As further validation, we studied performance in mutant models of progressive neurodegenerative diseases – Huntington's disease [TgN HD82Gln 81Dbo; referred to as HD mice] and amyotrophic lateral sclerosis [Tg SOD1G93A dl1/GurJ; referred to as SOD1 mice] – and in a mutant strain with subtle gait abnormalities, C-Snap25Bdr/H (Blind-drunk, Bdr).

Further evidence comes from microarray analysis of a D. rerio mutant model of haematopoiesis, cloche, which identified Cldng (topologically groups with M. musculus CLDN13/CLDN4 in our analysis) as differentially expressed between mutant and wild type zebrafish and predominantly found in erythroid cell lineages [54].

The developed wild type and mutant model of PTD provides an insight to understand the effect of mutations and resistance towards the protease inhibitors.

In addition to these contusion models high scores were for a murine SOD1(G93A) mutant model of Amyotrophic lateral sclerosis (ALS GEOEO accession GSE18597) and a murine model of prion disease (GEO accession GSE23182).

Supporting this notion, introduction of a mutation in NCoR that abrogates its interaction with TR [37] or administration of suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase [38], ameliorates phenotypic abnormalities (growth, bone development) in the murine TRα1-PV mutant model of RTHα.

The positive maximal LE, reported here, demonstrate that both the wt and cwo-mutant models of the Drosophila circadian clock are chaotic in LD and DD.

Therefore, the ZMP currently has mutant models for 46% of all protein-coding genes.