Sentence examples for mutant mice supporting from inspiring English sources

RT-PCR analysis showed that Muc16-lacZ chimeric transcripts and downstream lacZ transcripts were barely or not detected in the mutant mice (Supporting Text S1, Supporting Figure S1B).

There were no abnormalities in the structure of the mature anagen follicles in the Bmal1 or Clock mutant mice, supporting the idea that circadian clock genes are primarily involved in timing mechanisms during the telogen-anagen transition.

We also observed an increase in neuro-specific enolase 2 both in the cerebellum and in the serum of mutant mice, supporting its potential use as a biomarker of bilirubin-induced neurological damage.

As shown in Figure 8 figure supplement 1, Gli1-GFP expression was drastically reduced in Nfe2 mutant mice supporting the idea that platelet mutants have reduced dentate cells produced from Shh activation.

Indeed, we previously found that Pacinian corpuscles, a subtype of RA mechanosensory end organs in the periphery, are not formed in Ret, Gfra2, or Nrtn mutant mice, supporting that NRTN/GFRa2-RET cis signaling occurs in RA mechanoreceptors (Luo et al., 2009).

In this study, we were able to block DCF-DA fluorescence (which reads out reactive oxygen, NO, and reactive nitrogen species) using L-NAME in tissue sections from mutant mice, supporting our hypothesis that NOS and NO are relevant to the phenotypes described.

Experiments using the P-glycoprotein inhibitor cyclosporine A and P-glycoprotein null mutant mice supported the hypothesis that a functional association exists between P-glycoprotein trandporters and opiopioid-inducedperalgesia.

The potent and fast-acting efficacy of ECS in the mutant mice supports the predictive validity of the mice as a model of bipolar disorder.

Numerous studies based on single mutant mice support the notion that MSH2/MSH6 is the major MutS complex involved in CSR and SHM.

Primary T cells from both strains of mutant mice supported HIV-1 infection as long as secondary TCR signals were provided (Figure 4I).

Other studies in cells from double BH3-only mutant mice support the idea that combined activation of different BH3-only molecules and simultaneous engagement of different downstream effectors may be required for efficient cell death induction.