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A growing collective of TFs are involved in achieving intestinal crypt homeostasis and previously we have specifically shown a role of Myb, exploiting several Myb hypomorphic mutant mice, sustained survival of which allowed the analysis of adult tissues not possible with embryonically lethal MybKO mice and that complemented the inducible intestinal-specific MybKO studies.
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The Tokyo University professor has just unveiled mutant mice that have lost their innate fear of cats.
In addition, a significant number of PC spines lack synaptic contacts with PF terminals and multiple climbing fiber (CF) innervation to PCs is sustained in GluRδ2 mutant mice [13], [16] [18].
Further, arthritis was not sustained in toll-like receptor 4 (TLR4) mutant mice [ 16].
The analysis of inducible mutant mice thus demonstrated that continuous Nrg1 signalling is essential to sustain muscle spindles and maintain motor coordination in the adult.
The Per1 and Per2 genes are essential to sustain the circadian rhythm, and the behaviors of Per1−/−/Per2−/− double mutant mice are arrhythmic [11], [12].
Supplementary Figure 9 Non-Martinotti SST+ cells have normal axonal length in conditional Mafb mutant mice.
You've got some normal mice and some mutant mice.
B.Cha. provided Gnat1rd17Gnat2cpfl3 double mutant mice.
Generation and characterization of dickkopf3 mutant mice.
The heterozygous mutant mice were subsequently intercrossed to generate homozygous mutant mice (Fig. 1C).
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