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If a mutant cannot be distinguished from the original, it is called equivalent.

However, they also demonstrate that the biofilm-defect in a sarA mutant cannot be explained by its impact on either nuclease or proteases alone.

Many of these, e.g. the B3 TFs, have not yet been assigned a specific biological function (Table 3), and the significance of their down-regulation in the ashh2 mutant cannot be evaluated at present.

However, the lack of BOS1 activation with the pelBC mutant cannot be accounted for by differences in symptom severity since pelBC and pelDE mutants exhibited similar virulence on Arabidopsis (data not shown).

These observations indicate that the MTO phenotype displayed by the T192 mutant cannot be explained solely by a deficient locomotion and reveal that the increased frequency of TOs is a genuine trait of the T192 strain.

The infection rate and bacterial load in fleas infected with the y3730 mutant was not significantly different than in fleas infected with wild-type or hmsT mutant Y. pestis (Table 2); therefore the highly significant difference in biofilm-dependent blockage produced by the y3730 mutant cannot be accounted for by any decreased ability to produce a chronic infection in the flea gut.

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Fig. 3F shows that the NPM/B23 S4A-mutant cannot be phosphorylated by active Plk2.

While menin is required for Hsp70 expression, the results of epistatic studies indicate that the increase in genome instability observed in Mnn1 lack-of-function mutants cannot be accounted for by mis-expression of Hsp70.

Moreover, the total protein level of NOS isoforms is unchanged, indicating that the increase in basal NOS activity seen by NO fluorescent imaging in the mutants cannot be explained by a change in isoform expression.

In contrast, Δ6 displayed a rather low recovery and Δ7 was completely inactive, indicating that the two mutants cannot be rescued by slowing down the folding process (Fig 2D).

However, the failure of forebrain maintenance in these mutants cannot be attributed to the neural tube closure defect since Wnt1 Cre Dbx1DTA embryos, which also display an opened brain at E9.5 (data not shown), form a forebrain.

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