Sentence examples for mutation cannot be from inspiring English sources

Since the recurrence of the c.833T>C mutation cannot be explained by any known mutational hotspot in the vicinity of c.833T, a different mutational mechanism should be considered.

A mutation cannot be recognized by enzymes once the base change is present in both DNA strands, and, thus, a mutation cannot be repaired.

Alternatively, consider the case in which the advantageous mutation cannot be detected by currently used screening methods.

In contrast, the cavity created by simultaneous double alanine mutation cannot be compensated, which severely destabilizes the protein structure and results in reduction in Rev activity.

For instance, the adRP phenotype present in patients carrying the p.G56R mutation cannot be explained by a defect in DNA-binding alone [20] [22].

Within this G-run, the base position of the mutation cannot be defined, and all the InsGs are thus regarded as identical mutations; they will always be counted as one single mutation if occurring in the same animal.

The participant believes that mutations cannot be constructive (useful).

When chaperone becomes scarce, either because of increased need due to stress or due to a mutation in a chaperone, the accumulated destabilizing mutations cannot be buffered and the malfunctioning of proteins manifests in the mutant phenotype.

In addition, understanding the epigenetic mechanisms that underlie these alterations has also provided new therapeutic potential, even if the driver mutations cannot be targeted directly (e.g. HDACi, DNMT inhibitors) (Table 1) (Arrowsmith et al., 2012; Foulks et al., 2012; Helin and Dhanak, 2013; New et al., 2012; Plass et al., 2013).

Although most of these mutations cannot be prevented, the team stressed that early detection and treatment can prevent many cancer deaths, regardless of the cause.

As these mutations cannot be as easily recognized as non-synonymous mutations there is always the risk that they remain unidentified.