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Here, we review the role of active WNT signaling during murine lung development (summarized in Table 1).
Taken together, WNT signal components, including several antagonists, are involved in a variety of critical processes during murine lung development, including the onset of lung specification, branching morphogenesis, alveolar formation, and angiogenesis with tightly coordinated epithelial and mesenchymal expression patterns for each time point and developmental stage.
As a tissue-specificity control, functional gene sets in murine lung development and lung cancers were studied in parallel.
Here, we investigated the effect of lung mesenchyme-specific inducible deletion of Sox9 during murine lung development.
Based on the available data, we hypothesized an essential role for KLEIP in murine lung development and function.
Here, we report that Ang-1 appears important in normal murine lung development, and have established its tissue-level expression and localization patterns at key time-points.
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In this study, the authors conclude that de novo ceramide synthesis is essential for the development of murine lung emphysema [ 19].
Murine lung undergoes rapid growth in the first four weeks of life.
Similarly, Bonner et al. demonstrated that transcriptome wide analysis of gene expression by DNA array technology showed numerous patterns associated with lung development in murines.
We infected the mice with P. multocida, which eventually led to the development of septicemia, This murine lung infection model was also used to elucidate the magnitude of the fAUC0-24h/MIC index required for various effects.
Previously, we established that exposure to nicotine activates Raf and PKC pathways in Rat or murine lung epithelial or cancer cells, which facilitate the genesis and development of tumors [ 23- 26].
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