Sentence examples for murine lung model from inspiring English sources

In a murine lung model of bleomycin-induced fibrosis, Thy-1 deficient mice develop more severe lung fibrosis in comparison to wildtype littermates [19].

The objective of our study was to elucidate the pharmacokinetics and pharmacodynamics of marbofloxacin in a Pasteurella multocida infected murine lung model, and to estimate the magnitudes of pharmacokinetics-pharmacodynamics parameters associated with various effects.

von Bethmann and colleagues [ 46] reported that, in an isolated perfused murine lung model, ventilation with a transpulmonary pressure of 25 comparedmpared with 10 cmH2O lead to a significant increase in the concentrations of both TNF-α and IL-6 in the perfusate.

Acquired resistance to Kras suppression in a Kras-driven murine lung cancer model also involved increased YAP1 signaling.

Another PTX-based liposomal system was devised by solid lipid nanoparticles (composed of glycerol palmitostearate and 50% (w/w) polysorbate 80 to target tumors in a murine lung cancer model.

Using a highly metastatic murine lung carcinoma model, it was demonstrated that this receptor regulates several cellular functions that can impact on the metastatic potential of the cells, including cellular proliferation, anchorage-independent growth, cell migration, and invasion.

In our RAF-driven murine lung cancer model that does not progress spontaneously to an invasive or metastatic phenotype, we have shown previously that disruption of E-cadherin promotes progression to metastasis.

The in vitro findings were also reproduced in K-rasLA1 murine lung cancer model treated adenovirus-LETM1 via aerosol (Fig. 2A and 2B), suggesting that loss of ATP level in adenovirus-LETM1 infected cells causes AMPK activation.

As 50% of human NSCLC carry mutations in genes that encode activators of the mitogenic cascade (RAS-RAF-MEK-ERK) [12] and this cascade is known to induce a target gene of ß-catenin, c-MYC [13], we decided to directly examine the ability of c-MYC to promote tumor progression in our RAF-driven murine lung cancer model.

A previous study reported that treatment with ROCK inhibitor reduced the fibrosis score in a murine lung fibrosis model [ 7].

Acquired resistance to KRAS suppression in a KRAS-driven murine lung cancer model involves increased YAP1 signaling.