Sentence examples for murine mammary development from inspiring English sources

Examination of normal murine mammary development has indicated that c-Myc is expressed during pregnancy-associated proliferation and postlactational involution associated MEC apoptosis (Strange et al, 1992).

The EGFR is essential for murine mammary development, and EGF and other ligands are potent inducers of ductal growth [ 19], but EGF does not stimulate lobuloalveolar differentiation [ 20].

This observation is significant because both human and murine mammary gland development proceeds in this manner, by the outward growth of terminal end buds into the mammary fat pad (reviewed in (29, 30)).

Robinson et al [ 21] used Northern blot analyses, in situ hybridization, and immunocytochemistry to define TGF-β expression patterns during murine mammary gland development and differentiation to establish that all three mammalian TGF-β isoforms are expressed in the epithelium during all phases of mammary development.

The pattern of DGAT1 expression was unexpected because it is considered a QTL [ 75] for milk production traits, and is essential for murine mammary gland development and milk synthesis [ 76].

The action of cyclin D1 in cell cycle control, its role in murine mammary gland development and oncogenesis, its altered expression in half of all human breast tumours and in the earliest stages of breast oncogenesis, as well as its apparent involvement in the action of oestrogen, have led to numerous studies to ascertain whether cyclin D1 may serve as a biological marker in breast cancer.

In addition, PRL was shown to play a role in development of murine mammary tumours [ 7– 9].

We have conditionally deleted Brca2 and p53 within murine mammary epithelium, resulting in the development of naturally arising tumours from 6 months of age.

Overexpression of ATF3 in CK5-expressing cells of the murine mammary gland results in the development of squamous metaplastic lesions in nulliparous females, and in mammary tumors in biparous mice, suggesting that ATF3 acts as a mammary oncogene.

Overexpression of ATF3 in CK5-expressing murine mammary epithelial cells results in the development of squamous metaplastic mammary lesions in nulliparous mice, and in mammary tumorigenesis in biparous mice, suggesting that ATF3 acts as a mammary oncogene.

Development of the murine mammary gland begins after birth, when terminal end bud structures migrate through the fat pad until the entire gland is filled with an epithelial structure.