Sentence examples for murine challenge model from inspiring English sources

Extending these experiments to an H5N1 murine challenge model suggested that these responses, while protective, are both required in responding to more highly pathogenic influenza viruses.

We have previously shown that IsdB, a conserved protein expressed by Staphylococcus aureus, induces a robust antibody response which correlates with protection in a murine challenge model.

Here, we positively identified them as virulence factors that do not influence normal bacterial growth yet affect lethality in an intranasal murine challenge model.

We then performed a preliminary assessment of attenuation of CVD 910 by comparing the minimum lethal dose causing death in 50% of a group of BALB/c mice (LD50) for CVD 910 vs. CVD 908- htrA, using the hog gastric mucin intraperitoneal murine challenge model.

Paragraphs 3, 4, and 5 of the Discussion describe the limitations of the current in vitro and ex vivo models of Typhi replication, as well as results on Salmonella Typhimurium fitness estimates in a murine challenge model that showed reduced fitness of fluoroquinolone-resistant strains.

For example, the clearance of Streptococcus pneumoniae colonization may not depend on the humoral immune response, - and antibodies are not important in the clearance of Helicobacter pylori in a murine challenge model., Investigation of human genetic linked disease has implicated a role for CD4+ Th17 cells in the natural clearance of S. aureus.

These include the ability of cell-mediated immunity to protect against HPAI in the presence of the severe cytokine dysregulation associated with H5N1 influenza a question thus far asked only in murine challenge models [10], [11], [12] and extended here to ferrets.

Virus-like particles are strongly immunogenic and have been found to be protective in seasonal and highly pathogenic influenza virus murine challenge models [ 57].

We produced and evaluated recombinant HSV-2 viruses unable to engage HVEM, and applied the murine intravaginal challenge model to test the pathologic characteristics and acute immune response induced by these viruses.

Importantly, increased antibody titers correlated with enhanced survival in a murine disseminated challenge model.

Our aims were to characterize Foxp3+ Treg-cell activation in a murine intravenous challenge model of disseminated C. albicans infection, and determine the contribution to disease.