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mouse challenge model (Fig. 2).

These findings were confirmed in vivo in a Kunming mouse challenge model.

mouse challenge model also confirmed the differences in virulence between the non-invasive strain 1 and the highly virulent strains 1861 and 4496 (Fig. 1B).

mouse challenge model identified three distinct virulence phenotypes by comparing the virulence of a collection of serotype 1 isolates (Fig. 1A).

Intriguingly, the pilin subunit PilB of PI-2a was also reported to mediate resistance to cathelicidin antimicrobial peptide and phagocyte killing, to increase bloodstream survival, and to confer virulence in a mouse challenge model [31].

Since CT521 is 99% and CT443 97% homologous between Ct serovar D and MoPn, we continued by investigating the effect of this vaccine construct in the well established MoPn mouse challenge model.

This conclusion was confirmed by an in vivo Kunming mice challenge model.

In a mouse aerosol challenge model, mice immunized with both conjugates showed a significant enhancement of the clearance of strain 25238 from lungs as compared with the control mice.

Recombinant EV71 virus-like particles (rVLP) produced from baculovirus formulated either with CFA/IFA or alum elicited good virus neutralization titers in both mice and non-human primates, and were found to be protective in the suckling mouse EV71 challenge model.

The kidney is the principal target organ for infection in the mouse IV challenge model and, while sepsis has been evidenced as the major cause of death in the mouse model [9], the extent of kidney damage in animals showing severe symptoms is considerable and is likely to contribute to the overall pathology of the disease [9], [11].

Moreover, avoidance of the disulfide bond mismatch provided an additional 30% protective efficacy against RV infection in the mouse RV challenge model.