Sentence examples for multiple substitutions is from inspiring English sources

For calculating cooperativity, the effect of multiple substitutions is measured directly (observed value).

The authors also point that the number of codons with multiple substitutions is not expected to be high.

Therefore, we additionally employed a relaxed version of the RGC_CAMs denoted RGC_CAs where the requirement for multiple substitutions is lifted, of course, at the price of increased homoplasy (Rogozin et al. 2008).

As the effective number of taxa (hence the ability to detect multiple substitutions) is directly related to the number of known states per site, the higher the amount of missing data, the higher the risk of tree reconstruction artifact.

One likely explanation for the temporal differences in the rate estimates is that the number of multiple substitutions is underestimated for deep sections of the tree, so that the rate appears lower.> -wrap-foot> The abbreviations correspond to those in Figure  1.

To investigate alternative mechanisms by which A8 substitutions enhance activity, multiple substitutions were introduced.

Kimura correction for multiple substitutions was applied [56].

For a number of residues multiple substitutions were created, which almost in all cases produced the same effect.

The T184, S202 or M250 ETV signature substitutions did not display significant resistance in the absence of LVDr changes, establishing that multiple substitutions were required for phenotypic resistance leading to virologic breakthrough on ETV.

The Jukes-Cantor correction for multiple substitutions was applied.

Kimura correction for multiple substitutions was applied [ 33].