We found that assigning a mutation as (not) having a structural effect is very sensitive to precise structural details; where multiple structures are available for the same protein, one structure may indicate that a mutation has a value just below a cutoff while another structure has a value just above.
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A non-systematic identifier was considered ambiguous within a database if it appeared in multiple records in the database, i.e., if multiple structures were provided for the same identifier.
Character states were generally translated into a single EQ statement, but not uncommonly we noted that multiple aspects of a structure or multiple structures are described within a single character state, requiring the annotation of multiple EQ statements.
In such cases, multiple structures were taken to represent as many sub-parts of the physiological complex assembly as possible.
If multiple structures were predicted, we chose the structure with either the minimal free energy or with the best compatibility to similar sequences.
Regions of the protein surface where the organic probes consistently congregated across multiple structures were then identified as potential allosteric sites.
In addition to the system that generates warning sounds, a simple algorithm that informs the surgeon about the relative distance to multiple structures was tested, with positive impressions reported by the surgeon.
The consequent multiple species structures is evolutionary stable at the presence of the fluctuation.
A mean total velocity response spectrum for characterizing the mean absolute input energy of multiple-support structures is derived utilizing their pseudo-static response.
