Sentence examples for multiple substitutions at from inspiring English sources

Studies of multiple substitutions at G20 and neighboring positions highlight the essential contributions of a glycine-specific tight turn and adjoining inter-subunit side-chain hydrogen bonds to the stability and architectural specificity of the intertwined dimer.

The MSP-119 mutant proteins with single substitutions at positions 22 (Leu → Arg), 43 (Glu → Leu) and 53 (Asn → Arg) and the MSP-119 mutant protein with multiple substitutions at positions 27 + 31 + 34 + 43 (Glu → Tyr, Leu → Arg, Tyr → Ser, Glu → Leu); which had inhibitory epitopes; had the highest recognition.

Another challenge associated with rate estimation is the underestimation of the number of substitutions along some branches, as a result of multiple substitutions at some sites, particularly as phylogenetic distance (i.e. branch length) increases [29], [30].

In the case of JTT, the pairs of closely related sequences were used to count substitutions and the transition matrix was calculated by completely neglecting multiple substitutions at a site in a parsimony method.

Because MEAM1 and MED are closely related, multiple substitutions at the same site are highly unlikely.

Underestimation of branch lengths can result from uncounted multiple substitutions at some sites [ 23, 24].

Furthermore, substitution rates along lineages can be misestimated, particularly when multiple substitutions occur at some sites.

The better fit offered by the codon position partition scheme over the gene partition scheme indicates that the main source of heterogeneity lies in the codon positions, most probably because of multiple substitutions accumulating at third codon positions.

This concept requires an extraordinary stable protein architecture tolerating multiple substitutions or insertions at the primary structural level.

Most of the genetic variation in the four species was found in the 5′ portion of the Control Region, corresponding to a region of 210 bps, characterized by multiple substitutions (mutational hotspots) at the same sites.

The importance of considering multiple substitutions per replication at the error threshold was illustrated.