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Some of the PPIs identified by multiple studies, such as between Imp3 and Mpp10, and Imp4 and Mpp10, were also reported in different organisms such as Drosophila [6].
Furthermore, several miRNAs were identified in multiple studies, such as miR-34b and miR-146a.
So far, more than 60 QTLs for BMD have been reported on all chromosomes except chromosome Y [ 8], with a few replicated in multiple studies, such as 7p21-22, 15q13-13, 15q13, and Xq27 [ 8].
There are limitations associated with using data sets containing published genomes from multiple studies, such as the lack of control on sampling and isolate information, but these genomes, principally from clinical isolates, are from diverse lineages (Miragaia et al. 2007).
Given the concomitant issues of multiple testing, very large studies of tens of thousands of subjects will be required to evaluate gene-environment interactions, should they exist, and these will probably require the pooling of data from multiple studies (such as has been done by the Collaborative Group on Hormonal Factors in Breast Cancer).
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There are multiple studies indicating such changes, including in vivo mouse studies [ 30].
We aim to utilize these results in multiple-scattering studies, such as the interpretation of polarimetric and photometric phase effects of asteroids and other atmosphereless solar-system objects.
However, multiple studies already revealed such possibilities.
This in vivo result was corroborated by multiple in vitro studies such as colony assay in soft agar and [3H]-thymidine uptake.
Through multiple genetic association studies, such as the genome-wide association study (GWAS) we have discovered many common variants associated with complex disease; however, these variants confer very little disease risk and cumulatively explain a limited portion of heritability (Manolio et al., 2009).
Many of these parents say they believe vaccines cause autism, even though multiple studies have found no such link.
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