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Exact(8)
This combinatorial complexity also calls for coordinating multiple splicing decisions.
This diversity is particularly high when multiple splicing decisions cause a combinatorial arrangement of several alternate exons.
The goal of the present study was to identify, at a genomic scale, intronic motifs that may specifically regulate multiple splicing decisions in C. elegans.
Those might represent elements either lacking regulatory functions or with a specific role in the regulation of multiple splicing decisions that was not apparent in previous analyses.
Here, the Caenorhabditis elegans genome was surveyed in order to identify sequence elements that might play a specific role in the regulation of multiple splicing decisions.
Collectively, these data indicate that both the ACYCCACA octamers and pairs of distant ACYCCA and CCACA motifs are associated with multiple splicing decisions.
Similar(52)
First, the usage of specific IMMADs depends on the distance separating the multiple splicing decision sites.
The usage of specific motifs is not linked to the gene product function, but rather depends on the gene structure, since it is influenced by the distance separating the multiple splicing decision sites.
Motifs enriched in the MASS group were called IMMADs, for Intronic Motifs linked to Multiple Alternative splicing Decisions.
The existence of specific intronic sequence elements linked to multiple alternative splicing decisions is intriguing and suggests that these elements might have some specialized regulatory role during splicing.
The introns flanking alternate exons in transcripts whose maturation involves multiple alternative splicing decisions were compared to those whose maturation involves a single decision.
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multiple court decisions
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