Sentence examples for several splicing decisions from inspiring English sources

Indeed, in most instances, we know relatively little on the consequences of alternative splicing on protein functions, even less when several splicing decisions are combined.

In other words, the impact of several splicing decisions on the protein function is not simply the sum of the impact of each decision; rather, specific isoforms gain unique properties.

The results of the present study indicate that the sequence composition of introns at the vicinity of alternate exons is indeed different whether only one or several alternative splicing decisions are engaged.

This diversity is particularly high when multiple splicing decisions cause a combinatorial arrangement of several alternate exons.

In conclusion, this study suggests that several intronic cis-regulatory elements have a specific regulatory role associated with multiple alternative splicing decisions along single transcripts.

In conclusion, the present findings raise the intriguing possibility that several cis-regulatory elements, as well as potential corresponding trans-acting factors, are specialized in the regulation of multiple alternative splicing decisions.

Several splicing modulators with antitumor activity bind SF3B and thereby modulate splicing.

We further showed that PARP1 influences splicing decisions by modulating the chromatin structure7.

This removal is controlled in part by RNA-binding proteins that regulate alternative splicing decisions through interactions with the splicing machinery.

Physiological barriers to pol II elongation, such as repressive chromatin structure, can thereby similarly impact splicing decisions.

Imaging these alternative splicing decisions revealed unexpected mesenchymal-epithelial transitions in these primary tumors.