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Each gene-exon is regulated by one or multiple splicing regulators, from which one may hypothesize the existence of an alternative splicing regulatory network (SRN).
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In the future, it will be interesting to focus on the development of particular circuits and assess the temporal expression profiles of multiple other splicing regulators.
Families of alternative splicing regulators often contain multiple paralogs presumed to fulfill different functions.
Alternative splicings often occur in a spatiotemporal manner, and some are regulated by alternative splicing regulators.
Furthermore, GR expression level is regulated by several transcriptional factors and splicing regulators [ 35– 35].
Changes in lamin B1 levels induce through chromosome repositioning, modifications of the expression of multiple genes, including RAVER2, which is a modulator of PTB (20), and possibly other splicing regulators.
This second class of splicing-related NC-RNAs could be named "non-coding splicing regulators".
The sequestration of Muscleblind splicing regulators results in myotonic dystrophy.
Global analysis of positive and negative pre-mRNA splicing regulators in Drosophila.
For example, RBFOX proteins are part of a large assembly of splicing regulators (LASR).
Yardley, J. et al. Mutations of VMD2 splicing regulators cause nanophthalmos and autosomal dominant vitreoretinochoroidopathy (ADVIRC).
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